Supply High Quality Way 200070 Powder Material Hair Loss Treatment CAS#440122-66-7

Model NO.
CAS#440122-66-7
Appearance
Powder
Quality
Refined
Colour
White
Way 200070
Way 200070 Powder Supplier
Anti Hair Loss Way 200070
Way 200070 Price
Transport Package
PE Bag, Foil Aluminum Bag, Cardboard Drum
Specification
50g/100g/1kg/10kg/100kgs/1000kgs
Trademark
MT
Origin
China
Production Capacity
500kgs /Month
Reference Price
Please contact us for quote
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Product Description

99% Purity Anti Hair Loss WAY 200070 Powder Manufacturer CAS 440122-66-7

Supply High Quality Way 200070 Powder Material Hair Loss Treatment CAS#440122-66-7
Name WAY 200070  
CAS  440122-66-7
Purity  99%
Grade Standard  Medicine Grade
Sample   WAY 200070  Available
COA   WAY 200070   Available
Test Method  HPLC
Other Name   4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one
Appearance  White Powder
Brand  MT
Description WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
Related Catalog
Signaling Pathways   >>   Others   >>   Estrogen Receptor/ERR
Research Areas   >>   Neurological Disease
Target

IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1]

In Vivo Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4].
Animal Admin Rats: Beginning 1 wk after ovariectomy, animals are given a single daily sc injection of hydroxypropyl betacyclodextran [vehicle; 27% (wt/vol) in saline; DPN (2.0 mg/kg), S-DPN (2.0 mg/kg), R-DPN (2.0 mg/kg), WAY-200070-3 (2.0 mg/kg), or PPT (1.0 mg/kg) in a total volume of 0.2 mL. Three hours after the daily treatment injection on d 4-7, animals undergo behavioral testing[4]. Mice: WAY-200070 is dissolved in a 10% ethanol/90% miglyol solution. WAY-200070 or vehicle is injected subcutaneously at a volume of 10 mL/kg body weight. Male ERβKO, ERαKO (both in C57BL/6 background) and WT C57BL/6 mice are injected with vehicle or WAY-200070 (30 mg/kg s.c.). After 15 min, the animals are sacrificed and the striatum is dissected and quickly frozen in liquid nitrogen and stored at -70°C for subsequent assay[1].
References

[1].   Hughes ZA, et al. WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology. 2008 Jun;54(7):1136-42.

[2].   Clipperton Allen AE, et al. Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice. Psychoneuroendocrinology. 2010 Aug;35(7):1008-22.

[3].   Clipperton AE, et al. Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology. 2008 Sep;33(10):2362-75.

[4].   Weiser MJ, et al. Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology. 2009 Apr;150(4):1817-25.

  Chemical & Physical Properties

Molecular Formula C 13 H 8 BrNO 3
Molecular Weight 306.11200
Exact Mass 304.96900
PSA 66.49000
LogP 3.66850
Storage condition 2-8ºC
Supply High Quality Way 200070 Powder Material Hair Loss Treatment CAS#440122-66-7 Supply High Quality Way 200070 Powder Material Hair Loss Treatment CAS#440122-66-7 Supply High Quality Way 200070 Powder Material Hair Loss Treatment CAS#440122-66-7 Q1: Are you a manufacturer?
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