Glutathione (GSH), renowned as the "Mother of Antioxidants," has been proven to mitigate aging issues caused by oxidative stress. It also inhibits melanin formation through three mechanisms: potent antioxidant effects, elimination of free radicals, and detoxification of harmful substances in the liver, thereby restoring fair and radiant skin. However, as this molecule is a substrate for proteolytic enzymes, it is easily degraded after oral ingestion, resulting in low bioavailability.
Through persistent research, scientists have discovered a derivative of glutathione—acetylglutathione (SAG, also known as S-Acetyl-L-Glutathione)—which provides a protective layer for GSH. This compound remains more stable in the bloodstream and can be effectively absorbed by the human body, making it one of the most effective glutathione variants available on the market today.
Acetylglutathione is a derived and upgraded form of reduced glutathione. Acetylation refers to the process of transferring an acetyl group to the side chain of an amino acid. In the case of glutathione, acetylation typically involves attaching an acetyl group to the reactive sulfur atom, which significantly enhances its ability to remain intact in the intestines. At the same time, it allows for higher concentrations to be absorbed into the bloodstream, where it becomes effective. This modification also improves its stability in the digestive tract and enhances its absorption.
A key feature of acetylglutathione is its superior stability and absorbability compared to regular glutathione. It also lacks the unpleasant sulfhydryl (thiol) odor. Additionally, it can rapidly increase intracellular levels of reduced glutathione without increasing energy expenditure. It is particularly effective in replenishing glutathione levels in cells that have been depleted due to viral infections.