| Name | Clascoterone |
| CAS | 19608-29-8 |
| Purity | 99% |
| Grade Standard | Medicine Grade |
| Sample | Clascoterone Available |
| COA | Clascoterone Available |
| Test Method | HPLC |
| Other Name | CB-03-01 |
| Appearance | White Powder |
| Brand | MT |
| Description | Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters. |
|---|---|
| Related Catalog |
Signaling Pathways
>>
Others
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Androgen Receptor
Research Areas
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Endocrinology
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| References |
[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83. [2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 538.9±50.0 °C at 760 mmHg |
| Molecular Formula | C 24 H 34 O 5 |
| Molecular Weight | 402.524 |
| Flash Point | 179.3±23.6 °C |
| Exact Mass | 402.240631 |
| PSA | 80.67000 |
| LogP | 3.76 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.555 |
| cortexolone 17α-propionate |
| [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate |
| Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)- |
| 21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate |
| CB-03-01 |
| Cortexolone 17 alpha-propionate |
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