Product Name : Cytisine
CAS No. : 485-35-8
Appearance : Light yellow crystalline powder
Purity : 98%
Specifications : ISO 9001:2015 certified

Description :

Cytisine (chemical name: (1R,5S)-1,2,3,4,5,6-Hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one) is a quinolizidine alkaloid derived from plants of the Fabaceae and Berberidaceae families, such as   Sophora alopecuroides . With the molecular formula   C ₁₁ H ₁₄ N ₂ O   and a molecular weight of   190.24 g/mol , it is a pyri-dine derivative known for its broad pharmacological activities, including antiarrhythmic, antimicrobial, antiulcer, and leukocyte-enhancing effects.

Pharmacological Actions :

1. Cardiovascular Effects :

   • Antiarrhythmic : Reduces myocardial excitability, conductivity, and contractility, slowing heart rate and prolonging the refractory period.

   • Clinical Use : Treats ventricular tachycardia and functional palpitations.

2. Respiratory Stimulation :

   • Acts similarly to nicotine by reflexively stimulating respiration, with stronger effects than lobeline at equivalent doses.

   • Used in   0.15% aqueous solution   (intramuscular or intravenous injection) to treat respiratory arrest caused by trauma, cyanide poisoning, anesthesia, or infectious diseases.

3. Uterine Effects :

   • Induces uterine contractions, aiding in labor induction and managing postpartum hemorrhage.

4. Emerging Application - Smoking Cessation :

   • Gains international attention as a highly effective smoking cessation agent by mimicking nicotine's action on acetylcholine receptors, reducing withdrawal symptoms.

Clinical Applications :

• Emergency Medicine :

  • Revives respiratory and cardiovascular function in shock, collapse, or neonatal asphyxia.

• Obstetrics :

  • Manages uterine bleeding and facilitates childbirth.

• Chronic Disease Management :

  • Integrated into artificial hibernation therapy and nicotine addiction treatment protocols.

Quality Standards :

• Purity : ≥98% (HPLC).

• Impurity Profile : Strictly controlled to ensure compliance with pharmacopeial requirements.

• ISO 9001 Certified : Manufactured under rigorous quality management systems.

Packaging & Storage :

• Packed in airtight, light-resistant containers.

• Store in a cool, dry place (2-8°C), protected from light and moisture.

• Shelf life: 24 months under recommended conditions.

Note : Cytisine is a versatile alkaloid bridging traditional medicine and modern therapeutics. Its dual role in cardiovascular regulation and smoking cessation highlights its potential in both acute care and public health initiatives.

For detailed technical data or customized formulations, please contact our technical team.