Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) raw material with anti-inflammatory, analgesic and antipyretic effects. Below is its detailed English introduction:
1. Basic Information
Chemical Name: 2',4'-Difluoro-4-hydroxybiphenyl-3-carboxylic acid
Chemical Formula: C15H13F2NO3S

 
Molecular Weight: 250.20 g/mol
CAS Number: 22494-42-4
Synonyms: Dolobid; Diflunisalum; 2-(2,4-Difluorophenyl)-6-hydroxybenzoic acid
2. Physical and Chemical Properties
Appearance: Typically exists as a white to off-white crystalline powder.
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, methanol and acetone.
Melting Point: Approximately 214-218°C.
pKa: Has two dissociation constants, with pKa1 around 1.8 (carboxylic acid group) and pKa2 around 8.8 (phenolic hydroxyl group).
3. Mechanism of Action
As an NSAID, its core mechanism relies on inhibiting the activity of cyclooxygenase (COX), including both COX-1 and COX-2 isoenzymes. By blocking the conversion of arachidonic acid to prostaglandins, it reduces the synthesis of prostaglandins-substances that mediate inflammation, pain and fever-thereby exerting anti-inflammatory, analgesic and antipyretic effects.
4. Applications (as Raw Material)
Pharma Production: Primarily used as the active pharma ingredient for manufacturing oral solid preparations, such as diflunisal tablets and diflunisal capsules. These preparations are clinically used to relieve mild to moderate pain (e.g., osteoarthritis, rheumatoid arthritis, post-operative pain, toothache) and reduce fever.
Research and Development: Applied in pharma R&D fields, such as the study of new NSAID formulations (e.g., sustained-release preparations, topical preparations) or the exploration of its potential therapeutic effects in other diseases.
5. Safety and Handling
Hazards: May cause irritation to the eyes, skin and respiratory tract upon direct contact. Long-term or excessive exposure requires compliance with occupational protection standards.
Storage Conditions: Store in a cool, dry and well-ventilated area, away from direct sunlight, high temperatures and incompatible substances (e.g., strong oxidants).
Regulatory Compliance: Production, transportation and use must adhere to regional pharma raw material regulations (e.g., FDA, EMA, NMPA standards) to ensure quality and safety.

Packaging & Shipping

 

Company Profile

 

Hubei Highwin New Material Technology Co., Ltd. focuses on the research and development, production and sales of epoxy resin and other chemical raw materials.

We have our own R&D laboratory, by ordinating our suppiers all over the world and manufacturing products with cooperated based factories, we're keeping enhance our competitiveness in the market.
Before developing overseas sales, we have been rooted in chemical raw materials for more than 20 years and have already been one of the top suppliers in China after years of efforts.

There are a group of hard-working, motivated, and creative staff working not only for the company but also for you--our respectable customer and partner! Based on good service and high-quality products, we're widely praised and trusted by customers and keep long-lasting relationships with them.
 

R&D Center

 

FAQ

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