Basic Information

• Product Name : N,N-Dimethylacetoacetamide
• Alias : DMAA; Acetoacetic acid dimethylamide; 2,4-Dioxo-N,N-dimethylbutanamide
• Chemical Formula : C 6 H 11 NO 2
• Molar Mass : 129.16 g/mol
• CAS Number : 2044-64-6

• Appearance : Colorless to pale yellow transparent liquid or crystalline solid (at lower temperatures), with no strong pungent odor.
• Melting Point : 21-23°C (store as a liquid to avoid crystallization).
• Boiling Point : 214-216°C (decomposes upon heating under atmospheric pressure).
• Density : 1.04 g/cm³ (25°C).
• Solubility : Highly soluble in water, ethanol, acetone, chloroform, and other polar solvents; miscible with most organic solvents.
• Refractive Index : n 20D 1.452

• Pharmaceutical Intermediates :
  • Synthesis of anti-inflammatory drugs (e.g., pyrazolone derivatives like metamizole);
  • Preparation of antibiotics (e.g., cephalosporin side chains);
  • Key intermediate for antimalarial agents (e.g., chloroquine analogs).
• Agrochemicals :
  • Used in synthesizing herbicides, fungicides, and insecticides (e.g., pyrazole-based pesticides).
• Polymer Chemistry :
  • As a crosslinking agent or modifier for polymers (e.g., polyurethanes, polyesters);
  • Precursor for functional polymers with β-dicarbonyl groups.
• Organic Synthesis :
  • Building block for heterocycles (e.g., pyridines, pyrimidines) via cyclization reactions;
  • Used in the synthesis of dyes, pigments, and photographic chemicals.

• Health Risks :
  • Skin/Eye Contact : May cause irritation, redness, and pain; prolonged exposure may lead to burns.
  • Inhalation/Ingestion : Harmful if inhaled or swallowed; may cause respiratory irritation, nausea, or vomiting.
  • Toxicity : LD 50 (rat, oral) ≈ 1500 mg/kg (moderate toxicity).
• Environmental Risks :
  • Persistent in water; may be toxic to aquatic organisms.
  • Avoid release into soil or water systems.
• Fire and Explosion :
  • Combustible liquid; flash point ≈ 96°C.
  • Keep away from open flames and heat sources.

• Protection :
  • Wear chemical-resistant gloves, safety goggles, and protective clothing.
  • Use in a well-ventilated area or fume hood to prevent vapor inhalation.
• Storage :
  • Store in a tightly sealed container in a cool, dry place.
  • Keep away from strong acids, bases, and oxidizing agents.
• Emergency Handling :
  • For spills, absorb with inert material (e.g., sand) and dispose of properly.
  • In case of fire, use dry chemical, CO 2 , or foam extinguishers.

• Common Derivatives :
  • N,N-Dimethyl-3-oxobutanethioamide : Sulfur analog for preparing thiazole derivatives.
  • N,N-Dimethyl-3-oxopentanamide : Homologue with an additional methyl group (C 7 H 13 NO 2 ).
• Comparison with Related Compounds :

Packaging can be customized according to customer requirements.

Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.