high quality Bilastine powder material factory price
Product Description
|
Common Name
|
bilastine
|
|
CAS Number
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202589-78-4
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Molecular Weight
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463.612
|
|
Density
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1.2±0.1 g/cm3
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Boiling Point
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639.1±55.0 °C at 760 mmHg
|
|
Molecular Formula
|
C
28
H
37
N
3
O
3
|
Melting Point
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202 °C
|
|
MSDS
|
N/A
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Flash Point
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340.3±31.5 °C
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Use of bilastine
Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria. Target: Histamine H1 ReceptorBilastine binds to histamine H1-receptors as indicated by its displacement of [3H]-pyrilamine from H1-receptors expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell lines. The studies conducted on guinea-pig smooth muscle demonstrated the capability of bilastine to antagonise H1-receptors. Bilastine is selective for histamine H1-receptors as shown in receptor-binding screening conducted to determine the binding capacity of bilastine to 30 different receptors [1]. Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma protein binding of 84-90% [2].