Basic Information

• Product Name: N,N-Diisopropylethylamine (DIPEA)
• Chemical Formula : C 8 H 19 N
• Other Names : Diisopropylethylamine, Hünig's Base, DIPEA
• Appearance : Colorless to light yellow clear liquid
• Odor : Strong amine-like odor
• Solubility : Miscible with organic solvents (e.g., dichloromethane, toluene); slightly soluble in water.

• Density : 0.74 g/cm³ (25°C)
• Melting Point : -46°C
• Boiling Point : 127-128°C
• Refractive Index : 1.412 (20°C)
• Flash Point : 27°C (closed cup)
• pKa (Conjugate Acid) : ~11.2 (in water)

• Base Properties : As a tertiary amine, it acts as a moderate to strong organic base, capable of abstracting protons in acid-base reactions. Its steric hindrance (bulky isopropyl groups) makes it a "hindered base," reducing its nucleophilicity while preserving basicity.
• Reduced Nucleophilicity : Due to steric bulk, the nitrogen atom is less accessible for nucleophilic attacks, making it suitable for reactions where base activity is needed without nucleophilic side reactions (e.g., alkylation, acylation).
• Solubility Characteristics : Its organic solubility allows it to function in non-aqueous reaction media, while its moderate basicity (weaker than sodium hydride but stronger than triethylamine) makes it versatile in organic synthesis.

• Organic Synthesis :
  • Base in Condensation Reactions : Used in peptide synthesis, esterification, and amide formation to neutralize byproduct acids (e.g., HCl) and drive reactions forward.
  • Hindered Base for Selective Deprotonation : Preferentially abstracts protons from less sterically hindered sites, useful in reactions like aldol condensations or enolate formations.
  • Catalyst in Cyclization and Esterification : Promotes ring-closing reactions or facilitates ester synthesis under mild conditions.
• Pharmaceutical Industry :
  • As a reagent in drug intermediate synthesis, especially for molecules sensitive to strong nucleophiles.
• Polymer Chemistry :
  • Catalyst for urethane polymerization and epoxy resin curing.
• Electrochemistry :
  • Used as a supporting electrolyte in some electrochemical reactions due to its good solubility in organic solvents.

• Hazard Class : Flammable liquid; causes skin and eye irritation; harmful if inhaled or ingested.
• Storage : Store in a cool, ventilated place, away from oxidizing agents and acids; keep containers sealed to prevent vapor release.
• Handling :
  • Use in a fume hood to avoid inhaling vapors.
  • Wear protective gloves and goggles; avoid skin/eye contact (flush with water immediately if exposed).
  • Dispose of waste according to hazardous chemical protocols.

Packaging can be customized according to customer requirements.

Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.