Food Supplements CAS 328-50-7 Alpha Ketoglutaric Acid Powder Akg

Model NO.
ketoglutaric acid
EINECS
/
Appearance
Powder
Quality
Refined
Colour
White
Name
Alpha Ketoglutaric Acid Powder
Mf
C5h6o5
CAS
328-50-7
MOQ
1kg
Transport Package
Sea
Specification
99%
Trademark
HS
Origin
China
HS Code
2904201000
Production Capacity
100000
Reference Price
$ 36.45 - 40.50
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Product Description

Food Supplements CAS 328-50-7 Alpha Ketoglutaric Acid powder Akg
Product Name:    2-Ketoglutaric acid
Synonyms:    2-KETOGLUTARIC ACID;2-OXOGLUTARIC ACID;2-OXOPENTANEDIOIC ACID;A-KETOGLUTARIC ACID;Glutaric acid, 2-oxo-;Glutaric acid, alpha keto;-Ketoglutaricacid;α-Ketoglutaricacid
CAS:    328-50-7
MF:    C5H6O5
MW:    146.1
EINECS:    206-330-3
Melting point     113-115 °C
Boiling point     185.67°C (rough estimate)
density     1.2821 (rough estimate)
vapor pressure     0.01Pa at 25ºC
refractive index     1.3920 (estimate)
FEMA     3891 | 2-OXOPENTANEDIOIC ACID
storage temp.     2-8°C
solubility     H2O: soluble0.1g/mL, clear, colorless
form     Crystalline Powder
pka    2.47(at 25ºC)
color     White to slightly yellow
Odor    Odorless
Food Supplements CAS 328-50-7 Alpha Ketoglutaric Acid Powder Akg  
I. Chemical Structure and Properties \
Alpha-Ketoglutaric acid AKG
1. Structural Characteristics    - It is an α - keto acid, and its chemical name is 2 - oxoglutaric acid. Its chemical formula is C5H6O5.
2. Physical Properties    - It is usually a white crystalline or crystalline powder. It is soluble in water, slightly soluble in ethanol, and insoluble in ether. It has a certain acidity because the carboxyl group in its molecule can ionize hydrogen ions.
II. Role in Organisms
1. Role in the Tricarboxylic Acid Cycle (TCA Cycle)    - In the aerobic metabolism process of cell respiration, α - ketoglutaric acid is a key intermediate product of the tricarboxylic acid cycle. It is generated by the oxidative decarboxylation of isocitric acid under the action of isocitrate dehydrogenase. Then, α - ketoglutaric acid continues to participate in subsequent reactions and undergoes oxidative decarboxylation reaction catalyzed by the α - ketoglutarate dehydrogenase complex to generate succinyl - CoA. This process produces reduced coenzyme I (NADH) and carbon dioxide. NADH can enter the electron transport chain to produce ATP (adenosine triphosphate).   - For example, in the mitochondria of the human body, the TCA cycle is constantly operating, and α - ketoglutaric acid is like a "transfer station", promoting the process of energy metabolism and providing energy for cells.
2. Amino Acid Metabolism    - α - ketoglutaric acid is also very important in the synthesis and catabolism of amino acids. It can be interconverted with some amino acids through transamination. For example, a reversible transamination reaction can be catalyzed by glutamate dehydrogenase between glutamate and α - ketoglutaric acid. In this reaction, glutamate loses an amino group and becomes α - ketoglutaric acid, and at the same time, α - ketoglutaric acid gains an amino group to generate glutamate, which plays a key role in maintaining the balance of amino acids in the body.
3. Association with Other Metabolic Pathways    - It is also related to some other metabolic pathways. For example, in the process of glutamine synthesis, α - ketoglutaric acid can participate as a raw material. In some tissues, glutamine synthetase uses glutamate and ammonium ions and consumes α - ketoglutaric acid to synthesize glutamine, which is of great significance for the transport and metabolism of amnia.
  ltem Specification Result Method
Assay >99.00% 99.50% HPLC
B1Afatoxin B1 ≤5.0ppb Conforms LCMS
Appearance Fine Powder Conforms Organoleptic
Color White Powder Conforms Organoleptic
Odor&Taste Characteristic Conforms Organoleptic
Physical&chemical Characteristics
Particle Size 95%Through 80 mesh Conforms Sieving
Loss on Drying ≤5.0% 3.80% USP<731>
Ash ≤5.0% 3.20% USP<561>
Loose Density Actual Value 0.51g/'ml USP<616>
Tight Density Actual Value 3.20% USP<616>
Residual Solvents Actual Value 0.51g/ml USP<467>
Pesticide Residue Actual Value 0.69g'ml USP<561>
Heavy Metals ≤10ppm Conforms USP<231>
Lead(Pb) ≤1.0ppm Conforms USP<730>
Anic(As) ≤1.0ppm Conforms USP<730>
Mery(Hg) ≤0.1ppm Conforms USP<730>
Caum(Cd) ≤1.0ppm Conforms USP<730>
MicrobiologicalTests
Total plate Count <5000cfu/g Conforms USP<2025>
Ycast& Mold ≤100 cfu/g Conforms USP<2025>
E.Coli. Negative Negative USP<2025>
Salmonella Negative Negative USP<2025>
Staphylococcus Negative Negative USP<2025>
Conclusion Confomm to In-house standard
Food Supplements CAS 328-50-7 Alpha Ketoglutaric Acid Powder Akg
 

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